One-Pot Chemoenzymatic Conversion of Alkynes to Chiral Amines
نویسندگان
چکیده
A one-pot chemoenzymatic sequential cascade for the synthesis of chiral amines from alkynes was developed. In this integrated approach, just ppm amounts gold catalysts enabled conversion to ketones (>99%) after which a transaminase used catalyze production biologically valuable in good yield (up 99%) and enantiomeric excess (>99%). preparative scale (S)-methylbenzylamine (S)-4-methoxy-methylbenzylamine its alkyne form gave 59 92%, respectively, with ee > 99%.
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ژورنال
عنوان ژورنال: ACS Catalysis
سال: 2021
ISSN: ['2155-5435']
DOI: https://doi.org/10.1021/acscatal.1c03474